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Updated: Apr 3, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
C-H functionalization at sterically congested positions by the platinum-catalyzed borylation of arenes
Takayuki Furukawa1, Mamoru Tobisu2, Naoto Chatani1
1Department of Applied Chemistry, Faculty of Engineering, and ‡Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
Abstract:
Despite significant progress in the area of C-H bond functionalization of arenes, no general method has been reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, we report the development of the first platinum-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to a series of 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.
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