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Updated: Apr 3, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
IFNL4 rs368234815 polymorphism is associated with innate resistance to HIV-1 infection
Luis M Real1, Rocío Herrero, Antonio Rivero-Juárez
1aInfectious Diseases and Microbiology Clinical Unit, Valme Hospital, Seville bImmunogenetics Unit, Department of Experimental Biology, University of Jaen, Jaen cMaimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/Reina Sofia University Hospital, Cordoba dDepartamento de Enfermedades Infecciosas, Hospital Carlos III, Madrid eServicio de Medicina Interna, Hospital de la Santa Creu i Sant Pau, Barcelona fHuman Genetics Unit, Department of Basic Medical Sciences, University of Lleida IRBLleida, Lleida, Catalonia, Spain.
Abstract:
The interferon (IFN)L4 polymorphism rs368234815 is associated with hepatitis C virus (HCV) spontaneous clearance and response to IFN-based treatments. The role of this polymorphism in HIV-1 infection is controversial. We investigated whether genetic variation at IFNL4 is associated to HIV-1 acquisition. The HCV protective allele TT was associated with decreased likelihood of HIV-1 infection in male intravenous drug users [odds ratio (OR): 0.3; P = 0.006], and this association was not modified by the genotype of CCR5. These results suggest that genetic susceptibility to HCV and HIV-1 infection shares common molecular pathways.
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