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Improved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis
Hyung-Ju Cho1,2, Hyun Jin Min1, Hyo Jin Chung1
1Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
Objectives/Hypothesis:
We aimed to evaluate the effectiveness of low-concentration hypochlorous acid (HOCl) nasal irrigation compared to isotonic normal saline for pediatric chronic rhinosinusitis.
Study Design:
This was a randomized, prospective, active-controlled study.
Methods:
This study investigated the effectiveness of 4 weeks of low-concentration hypochlorous irrigation by analyzing five categorized subjective symptoms and x-ray findings in pediatric patients with rhinosinusitis. Thirty-seven patients were enrolled, and 26 patients successfully completed the study.
Results:
Total symptom scores significantly improved with both HOCl and normal saline nasal irrigation, but there was no difference between the two groups. X-ray scores also improved in both groups; improvement was much greater in the HOCl group than the placebo group.
Conclusions:
Nasal irrigation with HOCl is an effective adjuvant treatment compared to isotonic normal saline for pediatric sinusitis.
Level Of Evidence:
1b.
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