Related Experiment Videos
How to perform transabdominal chorionic villus sampling: a practical guideline.
Giovanni Monni1, Giorgio Pagani1, Valentina Stagnati1
1a Department of Prenatal Genetic Diagnosis and Fetal Therapy , Ospedale Microcitemico , Cagliari , Italy.
Summary
First-trimester genetic screening has increased chorionic villus sampling (CVS) demand. This guideline offers practical advice for the transabdominal (TA) CVS technique, based on extensive institutional experience with over 26,000 procedures.
Area of Science:
- Maternal-Fetal Medicine
- Prenatal Diagnostics
- Genetics
Background:
- Increased demand for first-trimester genetic screening for chromosomal abnormalities and single gene disorders.
- Chorionic villus sampling (CVS) is a key first-trimester placental biopsy procedure.
- Transabdominal (TA) CVS has become the preferred method over transcervical (TC) CVS.
Purpose of the Study:
- To provide practical guidelines for novice operators performing transabdominal CVS.
- To share expertise gained from over 30 years and 26,000+ TA-CVS procedures.
- To standardize and improve the safety and efficacy of TA-CVS.
Main Methods:
- Retrospective review of institutional experience with TA-CVS.
- Development of a practical procedural guideline based on accumulated expertise.
- Focus on techniques and considerations for successful TA-CVS.
Main Results:
- The institution has successfully performed over 26,000 TA-CVS procedures.
- Established a robust experience base over 30 years.
- Identified key elements for a practical TA-CVS guideline.
Conclusions:
- Transabdominal CVS is a well-established and frequently performed first-trimester procedure.
- A practical guideline can support new operators in performing TA-CVS effectively.
- Continued expertise sharing is crucial for advancing prenatal diagnostic procedures.