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Engineering Anti-myeloma Responses Using Affinity-Enhanced TCR-Engineered T Cells

Jesus F San Miguel1, Bruno Paiva1, Juan-Jose Lasarte1

  • 1Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, 31008 Pamplona, Spain.

Cancer Cell
|September 17, 2015
PubMed

NY-ESO-1 TCR-engineered T cells have shown activity in solid tumors. Recent work supports their use in multiple myeloma by showing that ex vivo antigen-specific expanded T cells traffic to and persist in bone marrow, are well tolerated, and produce promising response rates when infused after stem cell transplantation.

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