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Updated: Apr 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Risk factors for adverse effects of drugs: more research is necessary]
1Rotterdam.
Abstract:
When drugs are registered, relatively little is known about their adverse effects as clinical trials generally include only small numbers of patients and are of limited duration. New European legislation and the monitoring of adverse events are intended to enable the timely recognition of adverse effects of newly-registered drugs. However, many adverse effects of commonly-used older drugs are already well-known. Therefore, in order to improve the quality of health care, research should also be focused on the risk factors associated with developing such adverse effects.
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Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...