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Related Experiment Videos

On-demand drug delivery from local depots.

Yevgeny Brudno1, David J Mooney1

  • 1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 17, 2015
PubMed
Summary

Stimuli-responsive polymeric depots offer controlled drug release for local diseases. Advances in physical and pharmacological stimulation enable on-demand therapeutic delivery, improving treatment flexibility.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Stimuli-responsive polymeric depots enable on-demand therapeutic release for local disease treatment.
  • These systems offer precise control over drug dosing and release timing.
  • Current advancements focus on enhancing the responsiveness and versatility of these depots.

Purpose of the Study:

  • To review recent progress in stimuli-responsive polymeric depot systems.
  • To highlight advancements in physical and pharmacological stimulation for drug release.
  • To discuss the potential of these systems in improving localized disease therapy.

Main Methods:

  • Review of literature on stimuli-responsive polymers and drug delivery.
  • Analysis of systems triggered by physical stimuli (ultrasound, electric/magnetic fields, light).
Keywords:
DepotDrug deliveryElectricLightMagneticNucleic acidOn-demandPharmaceuticalPolymerStimulatedTherapeuticUltrasound

Related Experiment Videos

  • Analysis of systems triggered by pharmacological stimuli (nucleic acids, small molecules).

    • Main Results:

    • Development of polymeric depots responsive to various physical and pharmacological stimuli.
    • Demonstration of controlled, on-demand release of therapeutic payloads.
    • Potential for adjustable dosing based on disease progression or healing.

    Conclusions:

    • Stimuli-responsive polymeric depots represent a significant advancement in localized drug delivery.
    • Physical and pharmacological stimulation methods offer versatile control over therapeutic release.
    • These engineered systems promise improved treatment efficacy and patient management for local diseases.