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Do kidney stone formers have a kidney disease?
Anna L Zisman1, Andrew P Evan2, Fredric L Coe1
1Section of Nephrology, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.
Kidney International
|September 17, 2015
Summary
Kidney stones (nephrolithiasis) are common and linked to kidney disease. Evidence suggests stone formation actively damages kidneys, contributing to chronic kidney disease and end-stage renal disease (ESRD).
Area of Science:
- Nephrology
- Urology
- Pathology
Background:
- Nephrolithiasis affects 1 in 11 people, with known associations to hypertension, cardiovascular disease, and chronic kidney disease.
- Debate exists on whether kidney stone formation is a cause or consequence of kidney disease, despite epidemiological links to chronic kidney disease and end-stage renal disease (ESRD).
Conclusions:
- Kidney stone formation is increasingly recognized as a pathogenic process contributing to kidney disease.
- Genetic disorders like cystinuria and primary hyperoxaluria exacerbate kidney damage in stone formers.
- Understanding these mechanisms is crucial for managing nephrolithiasis and preventing kidney disease progression.
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