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Updated: Apr 3, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Specificity of vascular endothelial growth factor treatment for radiation necrosis
Carlos J Perez-Torres1, Liya Yuan2, Robert E Schmidt3
1Department of Radiology, Washington University, Saint Louis, United States.
Abstract:
Recently, radiation induced necrosis in the brain has been treated using bevacizumab, an anti-VEGF antibody. We validated the VEGF specificity by comparing the therapeutic efficacy of anti-VEGF with non-specific isotype control antibody. Additionally, we found that VEGF over-expression and RN developed simultaneously, which precludes preventative anti-VEGF treatment.
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