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Updated: Apr 3, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Predictive value of PWI for blood supply and T1-spin echo MRI for consistency of pituitary adenoma
Zengyi Ma1,2, Wenqiang He1,2, Yao Zhao1,2
1Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Introduction:
It is a common view that consistency and blood supply of pituitary adenoma (PA) can influence the surgical effect. The aim of this study was to determine whether MRI signal intensity (SI) was correlated to the consistency or blood supply of pituitary macroadenoma.
Methods:
Forty eight pituitary macroadenoma patients were underwent preoperative MRI, including precontrast and contrast-enhanced (CE) T1-spin echo (T1-SE) imaging, CE-sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) imaging, and perfusion-weighted imaging (PWI). The tumor consistency and blood supply were determined by neurosurgeons. The expression of collagen IV and MIB-1 was detected with immunohistology. The correlation of the relative SI (rSI) values (tumor to normal frontal white matter SI) and PWI data to the tumor consistency, blood supply, and the expression level of collagen IV and MIB-1 was statistically studied by Kruskal-Wallis rank test (K-W test).
Results:
A significant correlation was observed between the tumor consistency and the rSI on precontrast T1-SE imaging (P = 0.004) but not on CE T1-SE and CE SPACE imaging. The expression of collagen IV was also significantly associated with rSI on T1-SE imaging (P = 0.010). The blood supply was correlated with the relative CBV (rCBV) (P = 0.030). In addition, the expression of MIB-1 was correlated with rSI of CE T1-SE imaging (P = 0.007).
Conclusion:
Our results suggest that T1-SE imaging may be a simple and useful method for predicting consistency of PA. CBV value can provide helpful information for assessing the blood supply of pituitary macroadenoma.
Insights
Magnetic resonance imaging (MRI) signal intensity on T1-spin echo (T1-SE) can predict pituitary adenoma consistency. Perfusion-weighted imaging (PWI) relative cerebral blood volume (rCBV) aids in assessing pituitary adenoma blood supply.
Area of Science:
- Neuroradiology
- Neuro-oncology
- Endocrinology
Background:
- Pituitary adenoma (PA) consistency and blood supply impact surgical outcomes.
- Preoperative assessment of these factors is crucial for surgical planning.
Purpose of the Study:
- To investigate the correlation between MRI signal intensity (SI) and PA consistency and blood supply.
- To evaluate the utility of various MRI sequences in predicting PA characteristics.
Main Methods:
- Forty-eight PA patients underwent preoperative MRI, including precontrast/contrast-enhanced (CE) T1-spin echo (T1-SE), CE SPACE, and perfusion-weighted imaging (PWI).
- Tumor consistency and blood supply were assessed by neurosurgeons.
- Immunohistochemistry for collagen IV and MIB-1 was performed.
- Statistical analysis (Kruskal-Wallis test) correlated relative SI (rSI) and PWI data with tumor characteristics and marker expression.
Main Results:
- Tumor consistency correlated significantly with rSI on precontrast T1-SE imaging (P=0.004).
- Collagen IV expression associated with T1-SE rSI (P=0.010).
- Blood supply correlated with relative CBV (rCBV) from PWI (P=0.030).
- MIB-1 expression correlated with CE T1-SE rSI (P=0.007).
Conclusions:
- Precontrast T1-SE imaging offers a simple method for predicting PA consistency.
- PWI-derived rCBV is valuable for assessing pituitary macroadenoma blood supply.
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