Boronate affinity materials for separation and molecular recognition: structure, properties and applications

Area of Science:

• Materials Science
• Analytical Chemistry
• Biochemistry

Background:

• Boronate affinity materials are unique sorbents for separating cis-diol-containing compounds.
• They offer advantages like broad selectivity, reversible binding, and pH-controlled release.
• These materials are vital for analyzing biomolecules in metabolomics, glycomics, and proteomics.

Purpose of the Study:

• To critically survey recent advances in boronate affinity materials.
• To focus on fundamental considerations and progress in the last decade.
• To discuss the impact of ligand and support structure on material properties.

Main Methods:

• Review of recent literature on boronate affinity materials.
• Analysis of structure-property relationships.
• Discussion of applications in various fields.

Main Results:

• Boronate affinity materials exhibit significant advantages for cis-diol recognition.
• Material properties are tunable by modifying boronate ligands and supporting materials.
• Recent developments have expanded their applications in separation science and diagnostics.

Conclusions:

• Boronate affinity materials are powerful tools for analyzing cis-diol-containing biomolecules.
• Understanding structure-property relationships is key to optimizing their performance.
• These materials offer promising solutions for challenges in proteomics, metabolomics, and disease diagnostics.