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Updated: Apr 3, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Thermo/pH Dual Responsive Mixed-Shell Polymeric Micelles Based on the Complementary Multiple Hydrogen Bonds for Drug
Qiuhua Wu1, Xiuping Tang1, Xue Liu1
1Liaoning Province Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, No.66 Chongshan Mid-Road, Huanggu District, Shenyang, 110036, Liaoning Province, P. R. China.
Abstract:
Thermo/pH dual responsive mixed-shell polymeric micelles based on multiple hydrogen bonding were prepared by self-assembly of diaminotriazine-terminated poly(ɛ-caprolactone) (DAT-PCL), uracil-terminated methoxy poly(ethylene glycol) (MPEG-U), and uracil-terminated poly(N-vinylcaprolactam) (PNVCL-U) at room temperature. PCL acted as the core and MPEG/PNVCL as the mixed shell. Increasing the temperature, PNVCL collapsed and enclosed the PCL core, while MPEG penetrated through the PNVCL shell, thereby leading to the formation of MPEG channels on the micelles surface. The low cytotoxicity of the mixed micelles was confirmed by an MTT assay against BGC-823 cells. Studies on the in vitro drug release showed that a much faster release rate was observed at pH 5.0 compared to physiological pH, owing to the dissociation of hydrogen bonds. Therefore, the mixed-shell polymeric micelles would be very promising candidates in drug delivery systems.
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