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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
Published on: November 17, 2017
Nano-Systems for Advanced Therapeutics and Diagnosis of Atherosclerosis
Chauhan Gaurav, Bhandari Saurav, Rath Goutam
1Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India. amitkumargoyal1979@gmail.com.
Insights
Nanotechnology offers advanced targeted drug delivery and diagnostic tools for cardiovascular diseases (CVDs), improving upon conventional methods. Careful nanocarrier selection and scale-up are crucial for real-world success in managing atherosclerosis.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Medicine
Background:
- Cardiovascular diseases (CVDs) remain a leading global cause of death and morbidity.
- Atherosclerotic conditions like myocardial infarction and stroke are significant contributors to mortality.
- Conventional drug delivery systems show limited efficacy in managing these complex disorders.
Purpose of the Study:
- To explore nanotechnology-based therapeutic and diagnostic approaches for atherosclerotic diseases.
- To provide a descriptive overview of disease targets and suitable nanocarriers.
- To discuss mechanisms for enhancing the selectivity and targeting potential of nanocarriers.
Main Methods:
- Review of nanotechnology applications in cardiovascular disease management.
- Analysis of different nanocarrier systems, including their merits and demerits.
- Discussion of strategies for improving targeting efficiency in nanomedicine.
Main Results:
- Nanotechnology provides advanced targeted drug delivery and diagnostic tools for atherosclerosis.
- Rational selection of nanocarriers is critical for effective disease site targeting.
- Understanding nanocarrier properties is essential for successful therapeutic interventions.
Conclusions:
- Nanotechnology significantly impacts cardiovascular disease management.
- Further research into scale-up aspects is necessary for clinical translation.
- Targeted nanomedicine holds promise for improving outcomes in atherosclerotic conditions.
Abstract:
Cardiovascular diseases (CVDs) are the leading cause of death and morbidity worldwide. Atherosclerotic situations such as acute myocardial infarction(MI) and stroke are still major causes of death worldwide. Present therapeutic approaches based on conventional drug delivery systems are not efficient to control these disorders. With the technological advancement and intervention of nanotechnology, several fascinating areas are explored for the management of these disorders. Targeted drug delivery approaches and diagnostic tools presented by nanotechnology, certainly took the atherosclerotic disease management to next level. Criticality lies in the rationale selection of an appropriately designed nanocarrier for targeting a specific zone of disease. Manuscript provides a descriptive view of disease targets; nanotechnology based therapeutic and diagnostic approaches and different nanocarriers to accomplish this task. It is important to have the understanding of different classes of these nanosystems along with their specific merits and demerits. Mechanisms and approaches for improving the selectivity or targeting potential are also discussed. There is no doubt that nanotechnology is having great impact in this area, but it is equally important to rationalize its scale up aspects for a real world success.
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