Related Experiment Video
Updated: Apr 3, 2026

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
Published on: November 16, 2016
Interferon-gamma Immunotherapy in a Patient With Refractory Disseminated Candidiasis
Emilie P Buddingh1, Jenneke Leentjens, Jasper van der Lugt
1From the *Department of Pediatrics, Division of Infectious Diseases and Immunology, Sophia Children's Hospital, §Department of Pediatric Oncology, and ¶Laboratory of Medical Immunology, Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands; and Departments of †Internal Medicine and ‡Intensive Care Medicine, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, The Netherlands.
Abstract:
Despite advances in supportive care and novel antifungal agents, mortality caused by invasive Candida infection is high. A 3-year-old boy with disseminated Candida dubliniensis infection during induction chemotherapy for acute lymphoblastic leukemia deteriorated despite resolution of neutropenia and appropriate antifungal treatment. Monocyte human leukocyte antigen-DR expression was extremely low, suggesting immunoparalysis. Adjuvant immunotherapy with interferon-gamma restored the immune response, which was accompanied by clinical and radiographic recovery.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Antifungal Agents
Tumor Immunotherapy
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Immunodeficiency Diseases
There are three main causes of immunodeficiency...

