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Information processing in the CNS: a supramolecular chemistry?

¹ASL Napoli 2 Nord, Distretto 45, Via Santa Chiara, 80023 Caivano, Naples, Italy.

Cognitive Neurodynamics

|September 18, 2015

Summary

Central nervous system information processing may involve more than just the neural code. Action potentials dynamically coordinate networks, and molecular-level processes influence cognition.

Keywords:

Action potential Embodiment Information Macromolecule Neural code Processing Supramolecular

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Area of Science:

Neuroscience
Molecular Biology
Cognitive Science

Background:

Traditional theories posit action potentials and homogeneous neuronal assemblies define neural computation.
The
neural code
focuses on spike timing for information transmission.

Purpose of the Study:

To challenge the overemphasis on the neural code in information processing.
To propose that action potentials dynamically coordinate neuronal networks across hierarchical architectures.
To highlight the role of molecular and supramolecular processes in neural computation and cognition.

Main Methods:

Review of novel data challenging traditional neuroscience tenets.
Introduction of the concept of supramolecular chemistry in neural information processing.
Emphasis on intra-neuronal and extra-neuronal factors influencing neuronal computations.

Main Results:

Action potentials contribute to dynamic coordination and network interactions, not just message passing.
Information processing occurs at multiple levels, from macromolecules to population dynamics.
Intra- and extra-neuronal factors significantly impact neuronal computations, suggesting molecular messages have cognitive relevance.

Conclusions:

The brain's information processing is a complex interplay of electrical signaling and molecular dynamics.
Supramolecular chemistry offers a framework for understanding information storage and processing at the molecular level.
Neuronal heterogeneity implies unique molecular information processing within individual neurons and circuits, impacting computation.