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Novel bocaparvoviruses in rabbits
G Lanave1, V Martella1, S L Farkas2
1Department of Veterinary Medicine, University Aldo Moro of Bari, Km 3 St. for Casamassima, Valenzano 70010, Italy.
Veterinary Journal (London, England : 1997)
|September 19, 2015
Summary
A novel bocaparvovirus was identified in rabbits with enteric disease. This discovery aids in understanding rabbit diseases and informs diagnostic approaches for parvovirus infections in rabbits.
Area of Science:
- Veterinary Virology
- Molecular Diagnostics
- Rabbit Pathogen Discovery
Background:
- Bocaparvovirus, a genus within Parvoviridae, is linked to various diseases in humans and animals.
- The pathogenic role of bocaparvoviruses in rabbits remains largely unexplored.
Purpose of the Study:
- To identify and characterize a novel bocaparvovirus in rabbits exhibiting enteric disease.
- To determine the prevalence of this new virus in rabbit populations.
Main Methods:
- Metagenomic analysis of fecal samples from diseased rabbits.
- Development and application of a specific PCR assay for virus detection.
- Whole-genome sequencing and phylogenetic analysis of the identified virus.
Main Results:
- A novel bocaparvovirus was identified and its complete genome sequenced.
- The virus showed distant relatedness to known porcine bocaparvoviruses.
- Prevalence was detected in 28% of rabbits with diarrhea and 17% without.
- Two distinct bocaparvovirus populations/sub-types were identified.
Conclusions:
- The novel bocaparvovirus may play a role in rabbit enteric disease.
- Inclusion in diagnostic algorithms can improve understanding of rabbit health and production impacts.
- Further research is needed to elucidate the full pathogenic potential and impact on laboratory rabbits.
