Related Experiment Video
Updated: Apr 3, 2026
Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Smoking and philadelphia-negative chronic myeloproliferative neoplasms
Anders Lindholm Sørensen1,2, Hans Carl Hasselbalch1
1Department of Haematology, Copenhagen University Hospital Roskilde, Copenhagen, Denmark.
Objective:
A single-institution case-control study was conducted to test the hypothesis that a history of smoking was associated with a higher risk of developing MPNs compared to CLL.
Methods:
Cases (n = 323) were all MPN patients diagnosed in a 10-year period, and controls (n = 333) were all patients with CLL diagnosed during that same period. Odds ratios and 95% confidence intervals were calculated and adjusted for gender and age by logistic regression.
Results:
A significant association between a personal history of smoking and the risk of MPNs compared to CLL were observed for all MPNs (OR = 1.73, 95%CI 1.25-2.40) and for the WHO 2008 classified MPNs (OR = 1.64, 95%CI 1.16-2.30).
Conclusions:
No other larger case-control study has described a positive association between the risk of MPN and a history of smoking in the general MPN population. This association might be explained by the chronic inflammatory state and oxidative stress in response to smoking, eliciting genomic instability in the stem cell compartment and ultimately clonal evolution resulting in MPNs.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:23Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD: