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Systematic and Meta-Analytic Review: Medication Adherence Among Pediatric Patients With Sickle Cell Disease

Kristin Loiselle1, Jennifer L Lee2, Lauren Szulczewski2

  • 1Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center kristin.loiselle@cchmc.org.

Journal of Pediatric Psychology
|September 20, 2015
PubMed

Insights

Medication adherence in pediatric sickle cell disease (SCD) varies widely due to different assessment methods. Future research should standardize assessments and explore key factors influencing adherence.

Area of Science:

  • Pediatric Hematology
  • Pharmacology
  • Public Health

Background:

  • Sickle cell disease (SCD) requires consistent medication adherence for effective management.
  • Understanding adherence rates and influencing factors is crucial for improving patient outcomes.

Purpose of the Study:

  • To systematically review medication adherence rates in pediatric SCD patients.
  • To analyze adherence based on assessment methods and medication types.
  • To identify correlates of adherence for future research.

Main Methods:

  • Systematic review of 49 articles published between 1982 and February 2015.
  • Meta-analysis of 14 studies focusing on demographic, medical, and psychosocial factors.
  • Analysis of medication adherence rates across different assessment strategies.

Main Results:

  • Reported adherence rates varied significantly, from 12% to 100%.
  • Approximately 30% of studies identified associations between adherence and key correlates.
  • Effect sizes for these associations were generally small to moderate (r = .02–.53).

Conclusions:

  • Variability in assessment methods likely contributes to the wide range of reported adherence rates.
  • Standardized assessment strategies are needed for future pediatric SCD adherence studies.
  • Incorporating key correlates in future research is recommended to better understand and improve adherence.
Abstract

Keywords:
adherencechildrenmeta-analysissickle cell diseasesystematic review

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