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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
Nasal bacterial colonization in cases of idiopathic epistaxis in children
Payal Kamble1, Sonal Saxena2, Sunil Kumar1
1Department of Otorhinolaryngology-Head & Neck Surgery, Lady Hardinge Medical College & Associated Hospitals Shaheed Bhagat Singh Marg, New Delhi 110001, India.
Insights
Nasal Staphylococcus aureus colonization is linked to idiopathic epistaxis in children. This bacterial presence contributes to nasal inflammation, crusting, and bleeding, highlighting its role in pediatric nosebleeds.
Area of Science:
- Pediatric Otolaryngology
- Microbiology
- Nasal Pathophysiology
Background:
- Idiopathic epistaxis is common in children.
- The underlying causes of recurrent nosebleeds are not always clear.
- Nasal bacterial colonization is a potential contributing factor.
Purpose of the Study:
- To investigate the association between nasal bacterial colonization and idiopathic epistaxis in pediatric patients.
- To identify specific bacterial species involved in pediatric epistaxis.
Main Methods:
- A descriptive, hospital-based observational study.
- 112 pediatric patients (ages 4-16) were divided into control (no epistaxis) and epistaxis groups.
- Anterior nasal cavity swabs were collected for microbiological evaluation.
Main Results:
- A significant association was found between nasal Staphylococcus aureus colonization and idiopathic epistaxis.
- S. aureus colonization correlated with increased crusting and dilated blood vessels in the nasal septum of epistaxis patients.
Conclusions:
- Nasal Staphylococcus aureus colonization initiates pathological events including inflammation, crusting, and neovascularization.
- These changes can lead to nasal irritation, digital trauma, and subsequent epistaxis in children.
- S. aureus plays a significant role in the etiology of idiopathic epistaxis in pediatric populations.
Objectives:
To evaluate the role of nasal bacterial colonization in cases of idiopathic epistaxis in children.
Methods:
A descriptive, hospital based, observational study in our hospital was conducted on total 112 pediatric patients in the age group 4-16 years. Group A (control): 56 patients with no epistaxis; Group B (epistaxis): 56 patients with idiopathic epistaxis. A swab for microbiological evaluation was taken from the anterior nasal cavity of each child.
Results:
A highly significant association between nasal colonization with pathological Staphylococcus aureus and idiopathic epistaxis was found. The presence of pathological S. aureus colonization in the anterior nasal cavity was also associated with statistically significant number of crusting and presence of dilated blood vessels on the anterior nasal septum of children in epistaxis group.
Conclusion:
Nasal bacterial colonization with S. aureus leads to a sequence of pathological events i.e. low grade inflammation, crusting and new vessel formation. This leads to irritation in nasal cavity resulting in digital trauma and subsequently epistaxis and thus it plays an important role in causing idiopathic epistaxis in children.
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