Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A context-free model of savings in motor learning.

eLife·2026

Same author

Point-of-care early infant HIV diagnosis at birth in a pragmatic cluster-randomized trial in Mozambique and Tanzania: A comparative cost and cost-effectiveness study.

PLoS medicine·2026

Same author

Age-related impairments in visual recall depend on what you are remembering.

Neuropsychologia·2026

Same author

Using country-level variables to discover country clusters beyond traditional health policy and performance metrics: An unsupervised machine learning approach for HIV healthcare delivery and financing.

PLOS global public health·2025

Same author

The Role of Modality-specific Brain Regions in Statistical Learning: Insights from Intracranial Neural Entrainment.

Journal of cognitive neuroscience·2025

Same author

Sensory expectations shape neural population dynamics in motor circuits.

Nature·2025

Same journal

Opioid-Associated Hippocampal Injury: Past, Present, and Future Directions.

Hippocampus·2026

Same journal

Neural and Navigational Features Influencing the Novelty Induced Benefits on Episodic Memory.

Hippocampus·2026

Same journal

Intrinsic Persistent Firing in CA1 Encodes Elapsed Time Across Behaviorally Relevant Scales.

Hippocampus·2026

Same journal

Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat.

Hippocampus·2026

Same journal

Hippocampal NOP Receptor Activation Impairs Object Recognition Memory Acquisition.

Hippocampus·2026

Same journal

Effects of Corticotropin-Releasing Factor 1 Receptor Antagonism on In Vivo Dentate Gyrus Long-Term Potentiation in the TgF344-AD Rat Model of Alzheimer's Disease.

Hippocampus·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 3, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

Distributed category-specific recognition-memory signals in human perirhinal cortex.

Chris B Martin^1,2, Rosemary A Cowell³, Paul L Gribble^1,4

¹Department of Psychology, The Brain and Mind Institute, Western University, London, Ontario, Canada.

|September 20, 2015

Summary

This summary is machine-generated.

The perirhinal cortex (PrC) uses distributed patterns of both increased and decreased brain activity to represent previously encountered objects. This coding is category-specific for faces and links to better memory performance.

Keywords:

fMRI faces familiarity medial temporal lobe multivoxel pattern analysis

More Related Videos

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues

Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues

Published on: June 3, 2013

Related Experiment Videos

Last Updated: Apr 3, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

Published on: August 30, 2017

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues

Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues

Published on: June 3, 2013

Area of Science:

Neuroscience
Cognitive Psychology
Neuroimaging

Background:

The perirhinal cortex (PrC) is crucial for recognition memory, interfacing the medial temporal lobe with the ventral visual pathway for object identification.
The exact neural coding mechanisms within the PrC for object recognition remain incompletely understood.

Purpose of the Study:

To investigate whether the PrC codes for object prior occurrence using distributed activity patterns, including signal decreases and increases.
To determine if these neural patterns are tuned to specific object categories, such as faces.
To correlate neural coding patterns with behavioral recognition memory performance.

Main Methods:

Functional magnetic resonance imaging (fMRI) was employed to study brain activity in the PrC.
Multivoxel pattern analysis (MVPA) was used to decode recognition memory decisions from PrC activity.
Category specificity was assessed using independent functional localizers in a non-mnemonic task.

Main Results:

Activity patterns, including both signal increases and decreases, successfully classified recognition memory decisions.
Classification accuracy correlated positively with behavioral performance, indicating a link between neural patterns and memory.
Diagnostic voxels showed category-specific tuning for faces and were spatially distributed within the PrC.

Conclusions:

The findings support the hypothesis that the PrC uses distributed neural representations to code for the prior occurrence of objects.
These distributed representations are shaped by stimulus category, suggesting category-specific organization within the PrC.
The study advances understanding of the neural basis of recognition memory and object representation.