Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

8.3K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytotoxic CD39<sup>+</sup> tumor-associated NK cells respond to NKG2A blockade in lung cancer.

Science immunology·2026
Same author

[A new nomenclature for natural killer cells].

Medecine sciences : M/S·2026
Same author

NK cells promote cardiac cell death and regulate myelopoiesis in myocardial infarction.

Nature communications·2026
Same author

Glutathione is critical for NK cell-mediated immunity.

Cell reports·2026
Same author

Targeting BCMA in multiple myeloma with a trifunctional NK cell engager.

Cell reports. Medicine·2026
Same author

Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling.

Science immunology·2026

Related Experiment Video

Updated: Apr 3, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

10.8K

Lessons from NK Cell Deficiencies in the Mouse.

Florence Deauvieau1, Aurore Fenis1, François Dalençon2

  • 1Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, 13288, Marseille, France.

Current Topics in Microbiology and Immunology
|September 20, 2015
PubMed
Summary

New mouse models targeting NKp46-expressing cells, including natural killer (NK) cells and innate lymphoid cells (ILCs), offer improved study of immune responses. These models overcome limitations of older methods, advancing immunology research.

More Related Videos

Humanized NOD/SCID/IL2r&#947;null (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

16.5K
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

4.1K

Related Experiment Videos

Last Updated: Apr 3, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

10.8K
Humanized NOD/SCID/IL2r&#947;null (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

16.5K
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

4.1K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Traditional in vivo studies of mouse natural killer (NK) cells used depleting antibodies with limitations.
  • NKp46 is a key marker for NK cells across species, also found on innate lymphoid cells (ILCs) like ILC1 and NCR(+) ILC3.
  • Recent development of mouse models targeting NKp46-expressing cells has emerged.

Purpose of the Study:

  • To review advances in generating NKp46-deficient mouse models.
  • To discuss the application of these models in studying NK cell roles in immunity.
  • To explore the regulation of adaptive immune responses by NKp46-expressing cells.

Main Methods:

  • Review of recent literature on NKp46-deficient mouse models.
  • Analysis of studies utilizing these models to investigate immune functions.
  • Focus on models targeting NKp46-expressing cells, including NK cells and ILC subsets.

Main Results:

  • NKp46 serves as a reliable marker for NK cells and related ILCs.
  • Novel mouse models targeting NKp46-expressing cells have been successfully generated.
  • These models enable detailed investigation into NK cell-mediated immunity.

Conclusions:

  • NKp46-based mouse models represent a significant advancement over previous methods.
  • These models are crucial for dissecting the complex roles of NK cells and ILCs in immune regulation.
  • Future research will benefit from these tools to understand adaptive immunity modulation.