Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Aphasia of deep localization].

J A Saggese, E O Toboada, J E Duhart

    Neurologia (Barcelona, Spain)
    |September 1, 1989
    PubMed
    Summary

    This study on aphasia patients found that subcortical lesions, particularly basal ganglia involvement, can cause varied language deficits. Some patients experienced initial mutism or non-fluent speech, with common accompanying motor speech impairments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    CT or MRI in posttraumatic headache.

    Headache·2004
    Same author

    [Hyperprolactinemia in subclinical hypothyroidism].

    Medicina·2001
    Same author

    [Diagnostic value of tumor markers in pleural effusions].

    Medicina·1990
    Same author

    [Emphysematous pyelonephritis].

    Medicina·1987
    Same author

    [Plasma lipoproteins in alcoholic liver diseases].

    Medicina·1986
    Same author

    [Plasma clearance of radiocolloids in alcoholic hepatopathies].

    Medicina·1981

    Area of Science:

    • Neurolinguistics
    • Neuroimaging
    • Cerebral Computed Tomography (CT)

    Background:

    • Aphasia, a language disorder, often results from brain lesions.
    • Subcortical lesions, including those in the basal ganglia and thalamus, are implicated in various neurological conditions.
    • Understanding the specific impact of lesion location and volume on aphasia subtypes is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the neurolinguistic characteristics of aphasia in patients with predominant subcortical involvement.
    • To correlate lesion volume and topography with specific aphasia types and associated symptoms.

    Main Methods:

    • A cohort of 60 patients with aphasia underwent neurolinguistic assessment.
    • Cerebral computed tomography (CT) scans were utilized to identify and characterize the location and volume of brain lesions.
    • Patients were categorized based on lesion involvement (basal ganglia, thalamic, paracapsular) and aphasia presentation.

    Main Results:

    • Fourteen patients had predominant subcortical involvement; 6 with basal ganglia lesions (<5 ml) showed varied aphasia, including initial mutism or non-fluent speech.
    • These patients commonly presented with repetition difficulties, preserved comprehension, and motor speech deficits (dysarthria, dysprosody, hypophonia).
    • Larger paracapsular lesions (8 patients) were associated with global aphasia (mean 23.7 ml) or fluent aphasia (15 ml).

    Conclusions:

    • Subcortical lesions, even small ones in the basal ganglia, can lead to diverse aphasia profiles.
    • Motor speech impairments may persist longer than language deficits in some aphasia cases.
    • Lesion volume significantly correlates with the severity and type of aphasia observed.

    Related Experiment Videos