Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pattern visual evoked potentials and pattern electroretinograms in hypothyroidism.

G E Holder1, J R Condon

  • 1Department of Clinical Neurophysiology, Brook General Hospital, London, UK.

Documenta Ophthalmologica. Advances in Ophthalmology
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pattern ERGs suggest a possible retinal contribution to the visual acuity loss in acute optic neuritis.

Documenta ophthalmologica. Advances in ophthalmology·2022
Same author

Artificial scotoma estimation based on population receptive field mapping.

NeuroImage·2017
Same author

The pattern of retinal ganglion cell dysfunction in Leber hereditary optic neuropathy.

Mitochondrion·2017
Same author

Associations of mortality and cardiovascular disease risks with diabetes and albuminuria in urban Indigenous Australians: the DRUID follow-up study.

Diabetic medicine : a journal of the British Diabetic Association·2017
Same author

Eyetracker-based gaze correction for robust mapping of population receptive fields.

NeuroImage·2016
Same author

Congenital high myopia and central macular atrophy: a report of 3 families.

Eye (London, England)·2015
Same journal

Early onset primary angle closure and foveal retinoschisis associated with a pseudo-homozygous CRB1 pathogenic variant.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Bilateral perifoveal macular ischemia in non-proliferative Duchenne muscular dystrophy-associated retinopathy: a case report.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Association between dynamic pupil parameters and corneal sub-basal nerve plexus morphology.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Structure-function relationship between handheld photopic negative response and macular GCIPL thickness in chronic optic neuropathy.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Clinical course of a patient with PRSS56-associated nanophthalmos (isolated microphthalmia) and uveal effusion syndrome.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same journal

Congenital grouped albinotic spots of the retinal pigment epithelium-a case report.

Documenta ophthalmologica. Advances in ophthalmology·2026
See all related articles

Idiopathic hypothyroidism can affect vision, causing abnormal pattern electroretinography (PERG) and pattern visual evoked potentials (PVEP). Treatment with thyroxine normalized these visual function tests, suggesting reversible retinal dysfunction.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Neuroscience

Background:

  • Idiopathic hypothyroidism is a condition affecting thyroid hormone production.
  • Visual pathway dysfunction can occur in endocrine disorders.
  • Electrophysiological testing assesses visual pathway function.

Purpose of the Study:

  • To investigate pattern visual evoked potential (PVEP) and pattern electroretinography (PERG) findings in patients with idiopathic hypothyroidism.
  • To evaluate the effect of thyroxine treatment on visual function in these patients.

Main Methods:

  • PVEP and PERG were recorded in 10 patients with idiopathic hypothyroidism.
  • Eight patients underwent PERG testing.
  • Six patients were reassessed after treatment with thyroxine.

Related Experiment Videos

Main Results:

  • Initially, only one patient had abnormal PVEPs, but PERGs showed abnormal latency and subnormal amplitude in eight patients.
  • After thyroxine treatment, patients became euthyroid.
  • Repeat testing revealed normal PVEP and PERG results with significant improvements in latency and amplitude.

Conclusions:

  • Hypothyroidism may cause reversible central retinal dysfunction, impacting PVEP and PERG.
  • Thyroxine treatment can restore normal visual electrophysiological function.
  • PVEP delays in hypothyroidism are likely secondary to transient retinal dysfunction.