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Hepatitis C Virus Infection Is Associated With Increased Cardiovascular Mortality: A Meta-Analysis of Observational

Salvatore Petta1, Marcello Maida1, Fabio Salvatore Macaluso1

  • 1Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy.

Gastroenterology
|September 20, 2015
PubMed

Insights

Hepatitis C virus (HCV) infection increases the risk of cardiovascular disease (CVD)-related mortality and morbidity. This risk is particularly elevated in patients with co-existing diabetes and hypertension.

Area of Science:

  • Cardiology
  • Hepatology
  • Infectious Diseases

Background:

  • Conflicting results exist regarding the association between Hepatitis C Virus (HCV) infection and cardiovascular disease (CVD) risk.
  • HCV is a significant global health concern with potential systemic implications.

Purpose of the Study:

  • To systematically evaluate the association between HCV infection and cardiovascular morbidity and mortality through a meta-analysis.
  • To clarify the ambiguous findings from previous individual studies.

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed Central, Medline, Embase, Cochrane Library) up to July 2015.
  • 22 relevant studies were analyzed, extracting data on patient populations and outcomes.
  • A random-effects model was employed to synthesize data from the selected studies.

Main Results:

  • HCV-infected individuals exhibited a significantly higher risk of CVD-related mortality (OR, 1.65; P = .02).
  • Increased risks of carotid plaques (OR, 2.27; P < .001) and cerebrocardiovascular events (OR, 1.30; P = .002) were observed in HCV-infected patients.
  • The association between HCV and cerebrocardiovascular disease was amplified in populations with high prevalence of diabetes (>10%) or hypertension (>20%) (OR, 1.71).

Conclusions:

  • HCV infection is linked to an increased risk of cardiovascular morbidity and mortality.
  • The presence of diabetes and hypertension exacerbates the cardiovascular risk in individuals with HCV infection.
  • These findings underscore the importance of cardiovascular risk assessment in HCV patients, particularly those with comorbidities.
Abstract

Keywords:
Blood VesselChronic Liver DiseaseCirrhosisHeart Disease

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