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Overcoming the ABO incompatibility barrier in pediatric renal transplantation

Sidharth Kumar Sethi1, Pranaw Jha, Shyam Bihari Bansal

  • 1Kidney and Urology Institute; and *Renal Transplant Institute; Medanta, The Medicity Hospital, Gurgaon, Haryana, India. Correspondence to: Dr Sidharth Kumar Sethi, Pediatric Nephrology, Kidney and Urology Institute, Medanta, The Medicity Hospital, Gurgaon, Haryana 122 001, India. sidsdoc@gmail.com.

Indian Pediatrics
|September 22, 2015
PubMed

Insights

ABO-incompatible kidney transplants can be a viable option for children with end-stage renal disease. This case demonstrates successful pediatric ABO-incompatible renal transplantation in India.

Area of Science:

  • Nephrology
  • Transplantation Immunology

Background:

  • ABO blood type incompatibility is a significant barrier to kidney transplantation.
  • Pediatric end-stage renal disease (ESRD) presents unique challenges for finding compatible donors.

Observation:

  • A 12-year-old boy with ESRD (blood group B) received a kidney transplant from his mother (blood group AB).
  • The procedure involved a specialized desensitization and immunosuppressive protocol.

Findings:

  • The pediatric ABO-incompatible kidney transplant was successful.
  • The child exhibited stable graft function at 6 months post-transplant.

Implications:

  • ABO-incompatible kidney transplantation offers a crucial alternative for pediatric ESRD patients.
  • This case represents the first pediatric ABO-incompatible renal transplant reported in India, expanding treatment options.
Abstract

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