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Updated: Apr 3, 2026

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Pre-eclampsia and Future Female Malignancy.

Asnat Walfisch1, Roy Kessous2, Ehud Davidson3

  • 1a Department of Obstetrics and Gynecology , Hillel-Yaffe Medical Center affiliated with The Bruce and Ruth Rappaport Faculty of Medicine, Technion, Israel Institute of Technology , Hadera , Israel .

Hypertension in Pregnancy
|September 22, 2015
PubMed
Summary

Women with a history of pre-eclampsia (a pregnancy complication) do not face a higher risk of developing future genital tract or breast cancers. This study found no significant association between pre-eclampsia and these malignancies.

Keywords:
Breast cancerGenital malignancyGestational hypertensionLong-term follow upPregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Oncology
  • Epidemiology

Background:

  • Pre-eclampsia is a serious pregnancy complication.
  • The potential long-term health implications of pre-eclampsia require further investigation.
  • Existing research has not definitively established a link between pre-eclampsia and subsequent cancer risk.

Purpose of the Study:

  • To determine if a history of pre-eclampsia is associated with an increased risk of developing genital tract or breast malignancies.
  • To analyze the cumulative incidence of these cancers in women with and without pre-eclampsia.

Main Methods:

  • A cohort study comparing malignancy incidence in women with and without a pre-eclampsia history.
  • Utilized Kaplan-Meier survival curves to assess cumulative incidence.
  • Included over 100,000 deliveries, with 8.1% in patients with pre-eclampsia.

Main Results:

  • No statistically significant difference in the risk of genital tract or breast malignancies was observed between women with and without pre-eclampsia.
  • Sub-analyses based on malignancy type, pre-eclampsia severity, and episode frequency did not alter the findings.
  • Cumulative incidence curves showed no divergence between the groups.

Conclusions:

  • Pre-eclampsia does not appear to be a risk factor for the development of future genital tract or breast malignancies.
  • The findings suggest that pre-eclampsia does not influence the long-term risk of these specific cancers.