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Grossing of Non-neoplastic Globes, Including Fetal Eyes

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Bony orbital maldevelopment after enucleation.

Yongrong Ji¹, Fuxiang Ye¹, Huifang Zhou¹

¹Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Journal of Anatomy

|September 23, 2015

Summary

This summary is machine-generated.

Enucleation before age 18 significantly impacts bony orbital development and facial symmetry. Post-enucleation orbital maldevelopment is correlated with the age of the procedure, with potential volume reduction up to 20%.

Keywords:

enucleation facial asymmetry orbital development orbital volume

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Published on: October 6, 2014

Area of Science:

Ophthalmology
Plastic Surgery
Craniofacial Development

Background:

A common belief suggests early enucleation causes bony orbital maldevelopment and facial asymmetry.
The critical age range and extent of asymmetry following enucleation remain debated.

Purpose of the Study:

To investigate bony orbital development after unilateral enucleation without orbital implantation.
To determine the age threshold for significant orbital maldevelopment and quantify facial asymmetry.

Main Methods:

Analysis of 87 Chinese adult patients who underwent unilateral enucleation at various ages.
Measurement of bony orbital volume and orbital aditus area using 3D CT models.
Calculation of the orbital symmetry index (affected vs. unaffected orbit).

Main Results:

Bony orbits grow until approximately 18 years of age.
Enucleation before 18 years led to significant orbital maldevelopment (up to 20% volume reduction, 17% aditus area reduction).
Maldevelopment extent correlated with enucleation age, with derived regression formulae predicting asymmetry.

Conclusions:

Enucleation before skeletal maturity (around 18 years) causes significant orbital maldevelopment and asymmetry.
The study provides predictive formulae for orbital asymmetry based on enucleation age.
Findings aid in evaluating the necessity and efficacy of interventions for post-enucleation asymmetry.