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Updated: Apr 3, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
Targeted therapy in cancer
1Department of Investigational Cancer Therapeutics, Unit 455, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. atsimber@mdanderson.org.
Targeted therapies show promise in advanced cancer treatment, with ongoing clinical trials exploring novel agents. Advances in genomics and bioinformatics are key to developing more effective cancer drugs and precision medicine approaches.
Area of Science:
- Oncology
- Genomics
- Bioinformatics
Background:
- Cancer therapy has seen significant breakthroughs due to targeted therapies.
- Understanding carcinogenesis has been improved by technological advancements.
Purpose of the Study:
- To describe the emergence of targeted therapies in cancer treatment.
- To review clinical trials of novel agents for advanced cancer.
Main Methods:
- Systematic literature review.
- Analysis of clinical experience and relevant technologies.
Main Results:
- Genomics and model systems validate novel therapeutic strategies.
- Tumor molecular profiling aids in cancer reclassification and understanding treatment resistance.
- A gap exists between preclinical data and effective therapies due to drug development challenges and trial access limitations.
- Bioinformatic analyses can improve cancer diagnosis and treatment by characterizing tumor biology and dynamics.
- Translating cancer biology discoveries into clinical practice promises improved patient outcomes.
Conclusions:
- Combinations of targeted, immunomodulating, antiangiogenic, and chemotherapeutic agents are under clinical development.
- Innovative adaptive study designs are employed to accelerate drug development.
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