Related Experiment Video

Updated: Apr 3, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

11.2K

Chronic Invasive Aspergillus Sinusitis and Otitis with Meningeal Extension Successfully Treated with Voriconazole

Marjolaine Morgand1, Blandine Rammaert1, Sylvain Poirée2

  • 1Université Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, AP-HP, Paris, France.

Antimicrobial Agents and Chemotherapy
|September 23, 2015
PubMed

Insights

Invasive aspergillosis (IA) affecting the central nervous system can occur in patients with chronic renal failure or diabetes. Voriconazole monotherapy proved effective in treating these chronic IA forms without surgery.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Invasive aspergillosis (IA) is a severe fungal infection primarily affecting immunocompromised individuals.
  • Central nervous system (CNS) IA, characterized by meningitis and skull base involvement, presents unique challenges.
  • Chronic forms of CNS IA can affect patients with diabetes mellitus and chronic renal failure, beyond typical risk groups.

Observation:

  • Two cases of proven invasive aspergillosis involving the central nervous system were analyzed.
  • Patients presented with chronic forms of the disease, linked to diabetes mellitus and chronic renal failure.
  • Diagnostic markers, including cerebrospinal fluid and serum 1,3-β-d-glucan, were initially positive.

Findings:

  • Voriconazole monotherapy demonstrated effectiveness in treating both cases of CNS IA.
  • Successful treatment was achieved without the need for surgical intervention.
  • Galactomannan antigen test results were negative, contrasting with positive 1,3-β-d-glucan findings.

Implications:

  • This highlights voriconazole as a potential therapeutic option for chronic CNS IA, even without surgery.
  • The study underscores the utility of 1,3-β-d-glucan assays in diagnosing CNS IA in specific patient populations.
  • Recognizing non-traditional risk factors like diabetes and renal failure is crucial for early diagnosis and management of CNS IA.

More Related Videos

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung15:01

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung

Published on: September 18, 2021

3.9K
Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.4K

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
62
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
334
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
468