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Multicentric Metaplastic Breast Carcinoma with Squamous Differentiation.
Sunil Vitthalrao Jagtap1, Suresh J Bhosale2, P G Chougule2
1Professor, Department of Pathology, Krishna Institute of Medical Sciences University , Karad, Maharashtra, India .
Journal of Clinical and Diagnostic Research : JCDR
|September 23, 2015
Summary
Metaplastic breast carcinoma, a rare cancer, was diagnosed in a 45-year-old woman. This case highlights the importance of comprehensive evaluation for this aggressive malignancy.
Area of Science:
- Oncology
- Pathology
Background:
- Metaplastic breast carcinoma is a rare and aggressive subtype of breast cancer.
- This malignancy often presents diagnostic challenges due to its diverse histological features.
Observation:
- A 45-year-old female presented with multicentric breast lumps and axillary lymphadenopathy.
- Mammography showed suspicious masses; fine needle aspiration cytology indicated ductal carcinoma cells.
Findings:
- Histopathology confirmed multicentric infiltrating duct carcinoma with squamous differentiation, grade 2.
- Immunohistochemistry was negative for Estrogen Receptor (ER) and Progesterone Receptor (PR), but positive for HER-2/neu.
Implications:
- This case underscores the need for thorough clinicoradiological and histopathological correlation in diagnosing metaplastic breast carcinoma.
- Understanding the immunohistochemical profile is crucial for guiding treatment strategies in such rare breast cancers.
