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Updated: Apr 3, 2026
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Boron-selective reactions as powerful tools for modular synthesis of diverse complex molecules
Liang Xu1, Shuai Zhang, Pengfei Li
1Center for Organic Chemistry, Frontier Institute of Science and Technology (FIST) and Frontier Institute of Chemistry, Xi'an Jiaotong University, 99 Yanxiang Road, Xi'an, Shaanxi 710054, China. lipengfei@mail.xjtu.edu.cn.
Abstract:
In the context of modular and rapid construction of molecular diversity and complexity for applications in organic synthesis, biomedical and materials sciences, a generally useful strategy has emerged based on boron-selective chemical transformations. In the last decade, these types of reactions have evolved from proof-of-concept to some advanced applications in the efficient preparation of complex natural products and even automated precise manufacturing on the molecular level. These advances have shown the great potential of boron-selective reactions in simplifying synthetic design and experimental operations, and should inspire new developments in related chemical and technological areas. This tutorial review will highlight the original contributions and representative advances in this emerging field.
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