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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Natural compounds with Wnt signal modulating activity.

Rolly G Fuentes1, Midori A Arai, Masami Ishibashi

  • 1Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. mish@chiba-u.jp.

Natural Product Reports
|September 24, 2015
PubMed
Summary

Natural compounds can regulate the Wnt signaling pathway, which is crucial for biological processes and implicated in diseases like cancer. This review explores natural Wnt modulators and their mechanisms.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • The Wnt signaling pathway plays a vital role in numerous biological processes.
  • Dysregulation of Wnt signaling is linked to significant diseases, including cancer and neurodegenerative disorders.
  • Identifying therapeutic agents targeting Wnt signaling is a key research area.

Purpose of the Study:

  • To review natural compounds that modulate Wnt signaling activity.
  • To explore the potential mechanisms of action for these natural Wnt modulators.
  • To highlight recent advancements in natural product-based Wnt pathway research.

Main Methods:

  • Literature review of studies published up to 2015.
  • Focus on natural compounds identified through high-throughput screening.
  • Analysis of reported mechanisms of Wnt pathway regulation by natural compounds.

Main Results:

  • Several natural compounds have been identified as regulators of Wnt signaling.
  • These compounds exhibit diverse mechanisms for modulating Wnt activity.
  • Natural products offer a promising avenue for therapeutic development targeting Wnt-related diseases.

Conclusions:

  • Natural compounds represent a valuable resource for targeting the Wnt signaling pathway.
  • Understanding their mechanisms can lead to novel therapeutic strategies for cancer and neurodegenerative diseases.
  • Further research into natural Wnt modulators is warranted for drug discovery.