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Updated: Apr 3, 2026
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Fibroblast Growth Factor 23 and Incidence of Subarachnoid Hemorrhage: Nested Case-Control Study
Martin Söderholm1, Gunnar Engström2
1From the Cardiovascular Epidemiology Research Group, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden (M.S., G.E.); and Department of Neurology, Skåne University Hospital, Malmö, Sweden (M.S.). martin.soderholm@med.lu.se.
Background And Purpose:
Fibroblast growth factor 23 (FGF23) is a hormone with regulatory effects on mineral metabolism and arterial calcification. We aimed to study the association between FGF23 and risk of incident subarachnoid hemorrhage (SAH) in a nested case-control study.
Methods:
FGF23 was analyzed in stored blood samples from incident SAH cases (n=79) and control subjects (n=232), participating in the prospective, population-based Malmö Diet and Cancer Study. The association between FGF23 and SAH was studied using conditional logistic regression.
Results:
High FGF23 was associated with incident SAH. In the highest compared with the lowest quartile of FGF23, the odds ratio for SAH was 3.28 (95% confidence interval, 1.34-8.00), P for trend=0.006, after adjustment for SAH risk factors.
Conclusions:
High FGF23 was associated with increased risk of incident SAH in subjects from the general population. Further studies should elucidate whether FGF23 is a causal risk factor for SAH, or could be used in risk prediction.
