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Progress of iron-chelating therapy for iron overload in patients after bone marrow transplantation
Shi-wei Li1, Xiang Li2, Feng Guan1
1School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Abstract:
Bone marrow transplantation (BMT) is commonly used to treat hematopoietic system malignant diseases. Iron overload, which is one of the most common complications in patients undergoing BMT, has a negative impact on survival after allogeneic transplantation. Better understanding of molecular mechanisms of iron overload can improve the treatment regime and improve the efficiency for iron-chelating therapy. In this review, we summarize the mechanisms of iron overload in various conditions and the progression of iron-chelating strategies in patients undergoing BMT. This review will provide insights into the prevention and treatment of patients with iron overload after BMT.
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