Related Experiment Video

Updated: Apr 3, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.6K

Role of complement in glomerular diseases

Song Mao1, Jianhua Zhang1

  • 1a Department of Pediatrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , P.R. China.

Journal of Receptor and Signal Transduction Research
|September 25, 2015
PubMed

Insights

The complement system regulates immunity and protects against pathogens. Its dysregulation, particularly the alternative pathway, causes glomerular diseases, making anti-complement therapies crucial.

Area of Science:

  • Immunology
  • Nephrology
  • Molecular Biology

Background:

  • The complement system, comprising ~30 proteins, is vital for host defense against pathogens.
  • Complement dysregulation is linked to infections, autoimmune conditions, and glomerular diseases.
  • Alternative pathway defects specifically trigger complement activation in glomerular pathologies.

Purpose of the Study:

  • To elucidate the critical role of complement in the pathogenesis of glomerular diseases.
  • To provide a comprehensive overview of complement-related signaling pathways in these conditions.
  • To highlight the therapeutic potential of anti-complement strategies in nephrology.

Main Methods:

  • Literature review of complement system function and dysregulation.
  • Analysis of signaling pathways implicated in complement-mediated glomerular injury.
  • Synthesis of information on anti-complement therapies for glomerular diseases.

Main Results:

  • Detailed flowchart of complement signaling pathways presented.
  • Established link between complement alternative pathway dysregulation and glomerular damage.
  • Evidence supporting the efficacy of anti-complement therapies in various glomerular diseases.

Conclusions:

  • Complement system dysregulation is a significant driver of glomerular diseases.
  • Understanding complement signaling pathways is key to developing targeted therapies.
  • Anti-complement approaches offer promising treatment options for patients with glomerular conditions.

Keywords:
Complementglomerular diseasessignaling pathways

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.3K
Depletion of Specific Cell Populations by Complement Depletion06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.8K

Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
12.7K
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
9.1K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
988
Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.5K
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
86.3K
Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
3.9K