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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Updated: Apr 3, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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Anti-inflammatory Diets.

Barry Sears1

  • 1a Inflammation Research Foundation , Marblehead , Massachusetts.

Journal of the American College of Nutrition
|September 25, 2015
PubMed
Summary
This summary is machine-generated.

An anti-inflammatory diet, rich in omega-3s and polyphenols, can help manage chronic disease by balancing macronutrients and fatty acids. This approach targets inflammatory gene expression, promoting hormonal balance and satiety.

Keywords:
AA/EPA ratioHbA1cTG/HDL ratioanti-inflammatory dietmetabolic syndromeomega-3 fatty acidspolyphenols

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Area of Science:

  • Nutrition Science
  • Molecular Biology
  • Genetics

Background:

  • Chronic diseases are often linked to underlying inflammation.
  • Dietary macronutrient and fatty acid balance significantly influences inflammatory gene expression.
  • Specific dietary components can modulate key signaling pathways involved in inflammation.

Purpose of the Study:

  • To explore how dietary macronutrient and fatty acid ratios impact inflammatory gene expression.
  • To discuss the molecular targets and clinical outcomes of anti-inflammatory nutrition.
  • To highlight the role of diet as a gene-silencing technology for managing silent inflammation.

Main Methods:

  • Analysis of macronutrient balance (protein to glycemic load) and its effect on insulin and glucagon.
  • Investigation of omega-6 and omega-3 fatty acid ratios and their impact on eicosanoid formation.
  • Review of clinical studies on anti-inflammatory diets and their molecular targets, including NF-κB and AMP kinase.

Main Results:

  • Dietary protein and glycemic load influence hormonal responses (insulin, glucagon).
  • The balance of omega-6 and omega-3 fatty acids affects inflammatory eicosanoid production.
  • Anti-inflammatory diets, particularly those rich in omega-3s and polyphenols, reduce inflammation and target key molecular pathways.

Conclusions:

  • An anti-inflammatory diet, emphasizing omega-3s, polyphenols, and balanced macronutrients, is crucial for managing silent inflammation.
  • Stabilizing insulin and reducing omega-6 intake are key components of an effective anti-inflammatory strategy.
  • Dietary interventions can be viewed as a form of gene-silencing technology to restore hormonal and genetic balance, promoting satiety.