Resveratrol caused apoptosis in QGY-7701 cells
1Department of Oncology, People's Hospital of Xintai City, Affiliated to Taishan Medical University, Xintai, Shandong Province, P. R. China. shdljp@126.com.
Objective:
This study aims to evaluate the cytotoxicity of resveratrol in QGY-7701 cells using a cell viability assay and determine genetic damages after 24-h exposure to concentrations of 6, 12, and 24 µmol · L-1.
Materials And Methods:
Cell viability and genetic damages were determined using a WST-1 assay and Hoechst 33342 staining with single cell gel electrophoresis (SCGE), respectively. Reactive oxygen species (ROS) levels were also determined.
Results:
The results demonstrated that resveratrol inhibited QGY-7701 cell growth and decreased their viability in a dose-dependent manner. Furthermore, resveratrol caused nuclear morphological changes and DNA damage, promoted ROS levels, and induced cell apoptosis.
Conclusions:
These results suggest that resveratrol may induce QGY-7701 cell apoptosis by triggering excessive ROS generation and DNA damage.
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