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Aldosterone Impairs Vascular Smooth Muscle Function: From Clinical to Bench Research

Chia-Hung Chou1, Ying-Hsien Chen1, Chi-Sheng Hung1

  • 1Departments of Obstetrics and Gynecology (C.-H.C.) and Internal Medicine (Y.-H.C., C.-S.H., Y.-L.T., V.-C.W., C.-T.T., C.-K.W., Y.-L.H. K.-D.W., Y.-H.L.), National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Cardiology Division of Cardiovascular Medical Center (Y.-Y.C.), Far Eastern Memorial Hospital, New Taipei City, Taiwan; and Department of Internal Medicine (X.-M.W.), Taoyuan General Hospital, Taoyuan, Taiwan.

The Journal of Clinical Endocrinology and Metabolism
|September 25, 2015
PubMed
Summary

Aldosterone impairs vascular smooth muscle cell function by suppressing SERCA 2a expression. This leads to reduced vascular dilation, which is improved after adrenalectomy in primary aldosteronism patients.

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