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Related Experiment Video

Updated: Apr 3, 2026

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
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Adult-onset familial vocal fold paralysis.

Ida Amir1, Yanick J Crow, Pradeep Morar

  • 1Department of Otolaryngology-Head and Neck Surgery, NHS Lothian, Lauriston Place, Edinburgh EH3 9HA, UK. ida_lailaa@hotmail.com.

Ear, Nose, & Throat Journal
|September 25, 2015
PubMed
Summary

This study reports on adult-onset familial bilateral vocal fold paralysis in two brothers. The rare condition, presenting with stridor, suggests an autosomal recessive inheritance pattern.

Area of Science:

  • Neurology
  • Genetics
  • Otolaryngology

Background:

  • Bilateral vocal fold paralysis (BVFP) is a rare condition.
  • Adult-onset familial BVFP is exceptionally uncommon, especially without associated neurological or systemic features.
  • Vocal fold paralysis can lead to significant airway compromise.

Observation:

  • Two brothers, born to consanguineous parents, presented with acute stridor due to adult-onset bilateral abductor vocal fold paralysis.
  • Both patients had a history of adult-onset asthma, but otherwise, neurologic examinations and investigations were normal.
  • A third brother died from an airway issue at age 53, suggesting a potential familial pattern.

Findings:

  • This is the first reported case of adult-onset familial BVFP without associated neurological or other systemic features.

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  • The consanguinity of the parents strongly suggests an autosomal recessive inheritance pattern for this disorder.
  • The condition necessitated emergency surgical tracheostomy in both affected siblings.

    • Implications:

    • This case expands the known spectrum of familial BVFP and highlights the importance of considering genetic etiologies in adult-onset airway disorders.
    • The findings suggest a potential new genetic locus for autosomal recessive BVFP, warranting further molecular investigation.
    • Early recognition and diagnosis of this rare condition can prevent life-threatening airway obstruction and guide genetic counseling.