Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Heart Disease: Overview

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Underweight is associated with increased risk of all-cause dementia in older adults with vascular risk factors, independent of brain atrophy and small vessel disease.

Journal of Alzheimer's disease : JAD·2026

Same author

Remote Ischemic Conditioning for Acute Ischemic Stroke: The RICAIS Randomized Clinical Trial.

Journal of atherosclerosis and thrombosis·2026

Same author

[Brain Dock for Maintaining Activities of Daily Living in the Elderly].

Brain and nerve = Shinkei kenkyu no shinpo·2026

Same author

Catheter Ablation and Oral Anticoagulation for Secondary Stroke Prevention in Atrial Fibrillation: The STABLED Randomized Clinical Trial.

JAMA neurology·2026

Same author

Efficacy and Safety of IncobotulinumtoxinA for the Treatment of Blepharospasm: A Multicenter, Phase 3 Study in Japan.

Toxins·2026

Same author

Viral load and pathophysiology-based framework in varicella-zoster virus meningitis: Focus on altered consciousness and outcomes.

Journal of the neurological sciences·2026

Search research articles

Related Experiment Video

Updated: Apr 3, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Differences in Endothelial Function between Ischemic Stroke Subtypes.

Utako Adachi¹, Yukiko Tsutsumi², Mutsumi Iijima¹

¹Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|September 26, 2015

Summary

Endothelial dysfunction is linked to ischemic stroke. Impaired brachial artery function was observed in large artery atherosclerosis and cardioembolism stroke subtypes, but not small vessel occlusion.

Keywords:

FMD max-IMT plaque score stroke subtypes

More Related Videos

Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice

Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice

Published on: October 20, 2016

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

Published on: January 6, 2011

Related Experiment Videos

Last Updated: Apr 3, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice

Surgical Approach for Middle Cerebral Artery Occlusion and Reperfusion Induced Stroke in Mice

Published on: October 20, 2016

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

Published on: January 6, 2011

Area of Science:

Vascular Biology
Neurology
Cardiology

Background:

Endothelial dysfunction is a critical factor in ischemic stroke pathogenesis.
The specific impact of endothelial function on different stroke subtypes remains underexplored.

Purpose of the Study:

To investigate the relationship between endothelial function and specific ischemic stroke subtypes.
To compare endothelial function across large artery atherosclerosis (LAA), cardioembolism (CE), and small vessel occlusion (SVO) stroke types.

Main Methods:

Assessed brachial flow-mediated vasodilatation (%FMD) in 62 chronic stroke patients and 13 controls.
Classified stroke patients into LAA, CE, and SVO based on established criteria.
Analyzed %FMD differences considering sex, hypertension, and diabetes mellitus.

Main Results:

Patients with LAA, CE, and SVO showed significantly lower %FMD compared to controls.
Lower %FMD was noted in men versus women, and in patients with hypertension or diabetes.
After adjustments, LAA and CE groups exhibited reduced %FMD, unlike the SVO group.

Conclusions:

Conduit artery endothelial function is impaired in patients with LAA and CE stroke.
This impairment is present irrespective of co-existing vascular risk factors.
Endothelial dysfunction may differentially contribute to stroke subtypes.