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Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
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Cell Therapy: Targeting Endogenous Repair Versus Remuscularization

Konstantinos E Hatzistergos1, Joshua M Hare2

  • 1From the Department of Medicine, Division of Cardiology (J.M.H.), Department of Molecular and Cellular Pharmacology (J.M.H.), and Interdisciplinary Stem Cell Institute (K.E.H., J.M.H.), Leonard M. Miller School of Medicine, University of Miami, FL.

Circulation Research
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PubMed
Summary

No abstract available in PubMed .

Keywords:
Editorialscell- and tissue-based therapymesenchymal stromal cellsmyocardial infarctionmyocardium

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