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Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2

Nicolle H Rekers1, Catharina Ml Zegers1, Wilfred Tv Germeraad2

  • 1Department of Radiation Oncology (MAASTRO); Maastricht University Medical Centre ; Maastricht, The Netherlands.

Oncoimmunology
|September 26, 2015
PubMed

Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.

Keywords:
ED-Bcytotoxic T cellsimmune responseimmunotherapy

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