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Autocrine signaling of type 1 interferons in successful anticancer chemotherapy

Erika Vacchelli1, Antonella Sistigu2, Takahiro Yamazaki3

  • 1Gustave Roussy Cancer Campus ; Villejuif, France ; Université Paris XI, Faculté de Médecine; Le Kremlin Bicêtre , France ; INSERM; U1138 ; Paris, France.

Oncoimmunology
|September 26, 2015
PubMed

Anthracycline-based chemotherapies are particularly effective if they succeed in reinstating immunosurveillance by the induction of immunogenic cell death (ICD) in the tumor. Recently, we discovered that ICD is coupled to the induction of type 1 interferons (IFNs-I) that act in an autocrine fashion on cancer cells, thereby increasing their immunogenic potential.

Keywords:
IFNTLR3cancerimmunogenic chemotherapytumor immunity

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