Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

8.3K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
8.3K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

10.5K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
10.5K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

9.5K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.5K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.3K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.3K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

86.4K
Overview
86.4K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

4.4K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The evolving role of cytokines for CAR-T cell manufacturing and beyond.

Nature biomedical engineering·2026
Same author

Impact of ASO conjugation and receptor binding affinity on intracellular transport of mono- and bispecific TfR- and CD98-Brainshuttle<sup>TM</sup> variants.

mAbs·2026
Same author

First-in-human study of lomvastomig, a PD-1-TIM-3 bispecific antibody, in patients with advanced and/or metastatic solid tumors.

Journal for immunotherapy of cancer·2026
Same author

Target receptor expression dictates the selective intra-tumoral targeting of CD8<sup>+</sup> T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients.

Frontiers in immunology·2026
Same author

Tobemstomig, a Novel Bispecific Antibody, Preferentially Blocks PD-1 and LAG-3 on CD8 TILs to Expand Stem-like T Cells for Sustained Tumor Control.

Cancer research communications·2026
Same author

The INSPIRE doctoral network in safety pharmacology - Looking back and ahead.

Journal of pharmacological and toxicological methods·2026

Related Experiment Video

Updated: Apr 3, 2026

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

22.2K

How to outsmart NK cell tolerance.

Grzegorz Terszowski1, Christian Klein2, Laurent Schmied1

  • 1Department of Biomedicine; University Hospital Basel ; Basel, Switzerland.

Oncoimmunology
|September 26, 2015
PubMed
Summary
This summary is machine-generated.

Regulatory mechanisms induce immune tolerance, which can limit the effectiveness of therapies. This review explores strategies to overcome Natural Killer (NK) cell tolerance and improve antibody-dependent cellular cytotoxicity for enhanced therapeutic outcomes.

Keywords:
ADCCCD20HLAKIRNK cell tolerancelirilumabobinutuzumabrituximab

More Related Videos

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
11:02

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

6.5K
Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells
08:42

Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells

Published on: January 15, 2018

12.0K

Related Experiment Videos

Last Updated: Apr 3, 2026

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

22.2K
Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
11:02

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

6.5K
Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells
08:42

Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells

Published on: January 15, 2018

12.0K

Area of Science:

  • Immunology
  • Cancer Therapy

Background:

  • Immune tolerance is a critical aspect of the immune system, regulated by various mechanisms.
  • Therapeutic interventions can be hindered by the presence of immune tolerance.

Purpose of the Study:

  • To summarize strategies for enhancing antibody-dependent cellular cytotoxicity (ADCC).
  • To explore methods for overcoming Natural Killer (NK) cell tolerance in therapeutic contexts.

Main Methods:

  • Literature review of regulatory mechanisms in immune tolerance.
  • Analysis of strategies to modulate NK cell activity.
  • Examination of therapeutic antibody efficacy related to ADCC.

Main Results:

  • Immune tolerance can significantly impede the efficacy of immunotherapies.
  • Targeting NK cell tolerance presents a viable approach to boost ADCC.
  • Several strategies show promise in overcoming NK cell-mediated tolerance.

Conclusions:

  • Overcoming NK cell tolerance is crucial for maximizing the therapeutic potential of ADCC-based treatments.
  • Further research into these strategies could lead to more effective cancer immunotherapies.