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Updated: Apr 3, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer
Serena Lunardi1, Su Yin Lim1, Ruth J Muschel2
1Gray Institute for Radiation Oncology and Biology; Department of Oncology; University of Oxford ; Oxford, UK.
Abstract:
Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.
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