Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.4K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.4K
Neural Regulation01:37

Neural Regulation

44.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.9K
Decision Making01:20

Decision Making

1.2K
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
1.2K
Decision Making: P-value Method01:09

Decision Making: P-value Method

7.2K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can...
7.2K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Psychiatric Disorders and Apathy in Mixed Movement Disorders Linked to ADCY5 (MxMD-ADCY5).

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Effect on Dyskinesia of the Early Combination of Amantadine to Levodopa-Therapy in Parkinson's Disease: A Randomized, Placebo-Controlled Study (PREMANDYSK).

Movement disorders : official journal of the Movement Disorder Society·2025
Same author

ADCY5-Mosaic Variants: A Diagnosis Not to Be Missed.

Movement disorders clinical practice·2025
Same author

Motor and Non-motor Complications Following Different Early Therapies in Parkinson's Disease: Longitudinal Analysis of Real-Life Clinical and Therapeutic Data from the French NS-PARK Cohort.

CNS drugs·2025
Same author

Trial of Lixisenatide in Early Parkinson's Disease.

The New England journal of medicine·2024

Related Experiment Video

Updated: Apr 3, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

8.5K

Why do Parkinson's Disease Patients Sometimes Make Wrong Decisions?

Philippe Damier1,2

  • 1CHU Nantes, Centre d'investigation Clinique, Clinique neurologique, Nantes, France.

Journal of Parkinson'S Disease
|September 26, 2015
PubMed
Summary
This summary is machine-generated.

Parkinson's disease (PD) can impair decision-making due to dopamine system dysfunction, altering the balance of perceived benefits and costs. This can lead to impulsive choices and impulse control disorders in some patients.

Keywords:
Parkinson’s diseasedecision makingdeep-brain stimulationdopamineimpulse control disorderreinforcement learningsubthalamic nucleus

More Related Videos

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

16.5K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.3K

Related Experiment Videos

Last Updated: Apr 3, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

8.5K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

16.5K
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

23.3K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neurology

Background:

  • Decision-making involves weighing benefits against costs.
  • The dopamine system plays a crucial role in the decisional process.
  • Parkinson's disease (PD) is known to affect cognitive functions, including decision-making.

Purpose of the Study:

  • To explore how Parkinson's disease and its treatments affect decision-making processes.
  • To identify the neurobiological mechanisms underlying altered decision-making in PD patients.

Main Methods:

  • Review of current knowledge on the cerebral bases of decision-making.
  • Analysis of the role of the dopamine system in PD-related decision impairments.
  • Examination of the impact of dopamine agonists and subthalamic nucleus (STN) dysfunction on decision strategies.

Main Results:

  • Dopamine agonists can disrupt the benefit-cost analysis, leading to biased decision-making.
  • Subthalamic nucleus (STN) dysfunction, whether from dopamine replacement or deep brain stimulation, can impair decision-making, particularly in ambiguous choices.
  • Attention deficits and frontal lobe dysfunction in PD further contribute to altered decision-making.

Conclusions:

  • Parkinson's disease significantly impacts decision-making through various neurobiological pathways.
  • Understanding these alterations is crucial for managing PD and its associated behavioral changes, such as impulse control disorders.
  • Awareness among patients and caregivers is vital due to potentially detrimental consequences.