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Updated: Apr 3, 2026

An In Vitro Enzymatic Assay to Measure Transcription Inhibition by GalliumIII and H3 5,10,15-trispentafluorophenylcorroles
Published on: March 18, 2015
New platinum(II)-bipyridyl corrole complexes: Synthesis, characterization and binding studies with DNA and HSA
Bernardo A Iglesias1, Joana F B Barata2, Patrícia M R Pereira3
1Department of Chemistry and QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal; Departament of Chemistry, Universidade Federal de Santa Catarina, UFSC, 88040-970 Florianópolis, SC, Brazil; Departamento de Química, Universidade Federal de Santa Maria, UFSM, 97115-900 Santa Maria, RS, Brazil.
Abstract:
A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure.
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