Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.7K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.7K
Structure and Function of Platelets01:18

Structure and Function of Platelets

5.3K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
5.3K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

1.5K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioorthogonal tuning of nanosurface opsonisation <i>via</i> click coupling of a complement fusion protein inhibitor.

Chemical communications (Cambridge, England)·2026
Same author

Lipid nanoparticles engineered to target therapeutic RNA to the pancreas.

Nature·2026
Same author

The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.

Drug delivery and translational research·2026
Same author

A symphony of immunity: How HPV mRNA-LNP vaccination orchestrates systemic anti-tumor responses.

Molecular therapy. Nucleic acids·2026
Same author

cSMRTS for cancer therapeutics.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Exploring novel aromatase cytochrome P450-binding ligands: Molecular docking and QSAR study of phorbol esters as aromatase inhibitors.

European journal of medicinal chemistry·2025
Same journal

Dual PLGA nanoparticles co-encapsulating P5091 and Resveratrol synergistically target the USP7-MDM2-P53 axis for glioma therapy.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Regenerative polymer-based modalities for diabetic foot ulcers: From material design to clinical translation.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Mentha-derived green synthesized ZnO nanoparticles potentiate methotrexate induced molecular and migratory inhibition via gene expression modulation in T24 bladder cancer cells.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Fluvastatin-loaded chitosan-coated transfersomes for tumor-targeted nanotheranostics: Optimization, in-vitro cytotoxicity, and in-vivo radiokinetic evaluation.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Nanostructured lipid carriers of lutein-based dissolving microneedle patch: A promising approach for the management of rheumatoid arthritis.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Surface-charge-engineered magnetic silk fibroin nanocarriers for pH-responsive 5-fluorouracil delivery and in vitro magnetic localization.

Nanomedicine : nanotechnology, biology, and medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 3, 2026

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.3K

Platelet mimicry: The emperor's new clothes?

Seyed Moein Moghimi1, Alan Christy Hunter2, Dan Peer3

  • 1Centre for Pharmaceutical Nanotechnology and Nanotoxicology and Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.

Nanomedicine : Nanotechnology, Biology, and Medicine
|September 27, 2015
PubMed
Summary
This summary is machine-generated.

Platelet membrane-coated nanoparticles were evaluated for immune evasion and targeting capabilities. Findings suggest potential for improved nanoparticle design for enhanced therapeutic applications.

Keywords:
ComplementInnate immunityMacrophageNanoparticlesPlatelets

More Related Videos

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.3K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K

Related Experiment Videos

Last Updated: Apr 3, 2026

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.3K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.3K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.8K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Immunology

Background:

  • Investigating nanoparticle immune evasion strategies.
  • Assessing platelet membrane cloaking for nanoparticles.
  • Evaluating nanoparticle functionalities for in vivo applications.

Discussion:

  • Critical analysis of nanoparticle cloaking effectiveness.
  • Examining immune system recognition of coated nanoparticles.
  • Assessing platelet-mimicking functionalities for targeting.

Key Insights:

  • Platelet membrane coating's efficacy in immune evasion requires further validation.
  • Nanoparticles demonstrate potential for targeting damaged blood vessels.
  • Binding to opportunistic pathogens is a key functional assessment.

Outlook:

  • Developing improved nanoparticle design strategies.
  • Enhancing pharmaceutical viability of nanoparticle therapeutics.
  • Future directions in biomimetic nanoparticle engineering.