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Updated: Apr 3, 2026

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
Published on: June 5, 2019
Platelet mimicry: The emperor's new clothes?
Seyed Moein Moghimi1, Alan Christy Hunter2, Dan Peer3
1Centre for Pharmaceutical Nanotechnology and Nanotoxicology and Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Abstract:
Here we critically examine whether coating of nanoparticles with platelet membranes can truly disguise them against recognition by elements of the innate immune system. We further assess whether the "cloaking technology" can sufficiently equip nanoparticles with platelet-mimicking functionalities to include in vivo targeting of damaged blood vessels and binding to platelet-adhering opportunistic pathogens. We present views for improved, and pharmaceutically viable nanoparticle design strategies.
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