Related Experiment Video
Updated: Jun 17, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Bioorthogonal tuning of nanosurface opsonisation via click coupling of a complement fusion protein inhibitor
Sarah Jacques1, Hanmant Gaikwad1, Jemma Pillatzke2
1Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. seyed.moghimi@newcastle.ac.uk.
Abstract:
Complement opsonisation contributes to immune clearance of nanopharmaceuticals, but complement activation has some undesirable effects. Herein, we show that tethering the fusion complement receptor 2-complement receptor 1 (CR2-CR1) regulator to cross-linked iron oxide nanoworms via a PEG spacer and copper-free click chemistry overcomes complement opsonisation. Furthermore, CR2-CR1-conjugated nanoworms reduce complement opsonisation of unmodified nanoparticles.
Related Concept Videos
Complement System
Immunogold Electron Microscopy

