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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Apr 3, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

T-Cell Therapy: Options for Infectious Diseases.

Shreemanta K Parida¹, Thomas Poiret², Liu Zhenjiang¹

¹Therapeutic Immunology Division, Department of Laboratory Medicine, Karolinska Institutet.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|September 27, 2015

Summary

Drug-resistant tuberculosis poses a global threat. T-cell therapy, leveraging immune responses, shows promise for treating drug-resistant tuberculosis when conventional treatments fail.

Keywords:

CAR Mtb T-cells adoptive cell therapy host-directed therapy

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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

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Published on: May 27, 2011

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

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Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

Area of Science:

Immunology
Infectious Diseases
Cellular Therapy

Background:

Drug-resistant tuberculosis (DR-TB) presents a significant global health challenge.
Existing vaccines are insufficient for preventing Mycobacterium tuberculosis infection and disease.
Host-directed therapies are being explored as alternatives, especially for multidrug-resistant and extensively drug-resistant tuberculosis.

Purpose of the Study:

To review advancements in T-cell therapy.
To discuss the potential application of T-cell therapy in managing drug-resistant tuberculosis.
To explore T-cell therapy for patients with refractory tuberculosis unresponsive to standard treatments.

Main Methods:

Review of scientific literature on T-cell therapy.
Analysis of T-cell-mediated immune responses (CD8(+) and CD4(+) T cells).
Examination of recombinant immune recognition molecules, such as T-cell receptors and chimeric antigen receptors.

Main Results:

T-cell therapies have demonstrated safety and efficacy in other clinical settings, including cancer immunotherapy and viral infection prevention.
T-cell therapies utilize antigen-specific adaptive cellular immune responses.
Key achievements in T-cell therapy development have been identified.

Conclusions:

T-cell therapy represents a potential precision immunotherapy approach for drug-resistant tuberculosis.
This therapeutic strategy may offer new options for patients with limited prognoses due to refractory or drug-resistant tuberculosis.
Further research and clinical application of T-cell therapy are warranted for challenging tuberculosis cases.